Presentation Summary: Conventional methadone induction protocols, developed during the prescription opioid and heroin epidemics, are inadequately designed for the pharmacodynamic complexities of ultra-potent synthetic opioids like fentanyl. Our research directly addresses this critical gap by proposing an evidence-informed, high-dose rapid induction strategy in the outpatient setting that acknowledges the physiological realities of contemporary illicit drug markets.
Learning Objectives:
At the completion of this activity, participants will:
Evaluate the safety and efficacy of an accelerated methadone induction protocol for high-tolerance fentanyl-dependent patients.
Assess clinical outcomes, including treatment retention, withdrawal management, and potential adverse events.
Demonstrate a novel approach to OUD treatment that responds to emerging synthetic opioid market dynamics.
